It was the highest-selling album in Australia of 2003 The album also charted highly in the UK, peaking at number two.
In an exclusive interview with The Australian Women's Weekly, Goodrem revealed that, since 2002, she had suffered from a head-to-toe rash, fatigue, weight loss, night sweats, and a lump on her neck.
The news of her diagnosis made newspaper and television headlines and an outpouring of support was shown by fans and the general public alike.
Innocent Eyes is the best-selling album of the 2000s decade in Australia and the debut album with the most number-one singles.
Her second studio album, Mistaken Identity (2004), was created while she was suffering from cancer and several of its themes reflect this.
She began her career as a child actress, starring in various television shows and rose to prominence in 2002 in the Australian soap opera Neighbours as Nina Tucker.
Venturing into the music industry, Goodrem signed to Sony Music at the age of 15 and released her debut album, Innocent Eyes (2003), which topped the ARIA Albums Chart for an all-time record of 29 consecutive weeks and reached number two on the UK Albums Chart.
It became one of the highest-selling albums in Australian history, with over four million copies sold worldwide and all five of its singles—"Born to Try", "Lost Without You", "Innocent Eyes", "Not Me, Not I" and "Predictable—reaching number one on the ARIA Singles Chart and the first three reaching the top ten in the UK Single Chart.
This made Goodrem the first and only artist to have five number-one singles from a debut album.
In 2002, Goodrem took up the role as shy school girl and aspiring singer Nina Tucker in the popular soap Neighbours, which helped re-launch Goodrem's music career.
The piano-based ballad "Born to Try", co-written by Audius Mtawarira, premiered on the show and reached number one on the ARIA Singles Chart and number three in the UK.
Her first full-length DVD Delta became the highest-selling music DVD by an Australian artist in Australia ever, with a certification of 11x platinum.