In the 1990s, Griffin began performing as a standup comedian and also appeared as a guest star on several television shows.
She achieved recognition in a supporting role on the NBC sitcom Suddenly Susan (1996–2000).
Kathleen Mary "Kathy" Griffin (born November 4, 1960) is an American actress, comedian, writer, producer, and television host.
Griffin also starred in a dual role in a seventh-season episode of The X-Files and in an episode of ABC's divorce-attorney series Civil Wars, Griffin's dramatic-series debut.
After starring in an HBO Half Hour Comedy Special, Griffin had her first consistent public exposure in 1996, when she was cast as the acerbic colleague of Brooke Shields' title character on the NBC sitcom Suddenly Susan.
In the same book, Griffin discussed her eldest brother, Kenny, who was a drug addict and homeless at various times, and revealed that she was "afraid of him until the moment he died" due to his violent, abusive nature.
Griffin states that Kenny would climb into bed with her when he was 30 and she was 7 and "whisper" into her ears; Kathy refused to speak to him or be in the same room as him for years but didn't tell her parents until she was in her twenties, at which point he openly admitted pedophilia to their parents. Bernadine's Elementary School and began to develop a dislike for organized religion because of the punishments she and other "vulnerable" students received from the nuns.
Griffin is known for her conversational style and controversial statements on celebrities, religion and sexuality.
After being nominated for six years in a row for the Grammy for Best Comedy Album, she won the award in 2014, becoming only the third woman to win the category (the others being Lily Tomlin and Whoopi Goldberg).
She appeared in fellow comedian Julie Brown's Medusa: Dare to Be Truthful, a Showtime parody of the 1991 Madonna film Truth or Dare.
Griffin then had two appearances as the character Susan Klein, a reporter, on NBC's The Fresh Prince of Bel-Air, her TV sitcom debut.
While Kathy was a Groundling, she became best friends with Judy Toll.